Title of article
Evaluation of fosmidomycin analogs as inhibitors of the Synechocystis sp. PCC6803 1-deoxy-d-xylulose 5-phosphate reductoisomerase Original Research Article
Author/Authors
Youn-Hi Woo، نويسنده , , Roberta P.M. Fernandes، نويسنده , , Philip J. Proteau، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
11
From page
2375
To page
2385
Abstract
Analogs of the antibiotic fosmidomycin, an inhibitor of the methylerythritol phosphate pathway to isoprenoids, were synthesized and evaluated against the recombinant Synechocystis sp. PCC6803 1-deoxy-d-xylulose 5-phosphate reductoisomerase (DXR). Fosfoxacin, the phosphate analog of fosmidomycin, and its acetyl congener were found to be more potent inhibitors of DXR than fosmidomycin.
Keywords
Isoprenoid biosynthesis , Reductoisomerase , Fosmidomycin , Methylerythritol phosphate pathway
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2006
Journal title
Bioorganic and Medicinal Chemistry
Record number
1305608
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