Title of article
Synthesis and in vitro evaluation of pseudosaccharinamine derivatives as potential elastase inhibitors Original Research Article
Author/Authors
Haridas Rode، نويسنده , , Stefanie Koerbe، نويسنده , , Anita Besch، نويسنده , , Karen Methling، نويسنده , , Jutta Loose، نويسنده , , Hans-Hartwig Otto، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
10
From page
2789
To page
2798
Abstract
Pseudosaccharinamine derivatives were evaluated for elastase inhibitory activity. Ester derivatives of pseudosaccharinamine displayed reversible and high inhibition of human leukocyte elastase (HLE) as compared to porcine pancreatic elastase (PPE). Cyanomethyl (2S,3S)-2-(1,1-dioxobenzo[d]isothiazol-3-ylamino)-3-methylpentanoate was found to inhibit HLE at Ki = 0.8 μM.
Keywords
Pseudosaccharinamines , Elastase inhibitors , amino acid derivatives , Heterocycles
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2006
Journal title
Bioorganic and Medicinal Chemistry
Record number
1305650
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