Title of article
Synthesis, metal complexation and biological evaluation of a novel semi-rigid bifunctional chelating agent for 99mTc labelling Original Research Article
Author/Authors
Julien Le Gal، نويسنده , , Sandra Michaud، نويسنده , , Marie Gressier، نويسنده , , Yvon Coulais، نويسنده , , Eric Benoist، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
6
From page
2904
To page
2909
Abstract
A novel bifunctional chelating agent bearing an aromatic ring has been synthesised and characterised. This ligand formed well-defined oxorhenium complexes. The analogous 99mTcO-complex was obtained in an excellent yield with high radiochemical purity (>95%). The biodistribution of the 99mTc-complex after intravenous injection studied in normal rats showed that the activity was excreted mainly via renal-urinary pathway indicating its use for labelling peptides with 99mTc.
Keywords
Metallic complexes , Radiopharmaceuticals , Technetium-99m , Rhenium , Bifunctional chelating agent
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2006
Journal title
Bioorganic and Medicinal Chemistry
Record number
1305661
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