Title of article
Interaction of arylpiperazine ligands with the hydrophobic part of the 5-HT1A receptor binding site Original Research Article
Author/Authors
Mario V. Zlatovic، نويسنده , , Vladimir V. Sukalovic، نويسنده , , Christoph Schneider، نويسنده , , Goran M. Roglic، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
8
From page
2994
To page
3001
Abstract
A flexible docking of a series of arylpiperazine derivatives with structurally different aryl part to the binding site of a model of human 5-HT1A receptor was exercised. The influence of structure and hydrophobic properties of aryl moiety on binding affinities was discussed and a model for ligand binding in the hydrophobic part of the binding site was proposed.
Keywords
Arylpiperazine , 5-HT1A , hydrophobic pocket , Binding site
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2006
Journal title
Bioorganic and Medicinal Chemistry
Record number
1305670
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