Title of article
Synthesis and glycogen phosphorylase inhibitory activity of N-(β-d-glucopyranosyl)amides possessing 1,4-benzodioxane moiety Original Research Article
Author/Authors
Zolt?n Czak?، نويسنده , , L?szl? Juh?sz، نويسنده , , ?gnes Kenéz، نويسنده , , Katalin Czifr?k، نويسنده , , L?szl? Soms?k، نويسنده , , Tibor Docsa، نويسنده , , P?l Gergely، نويسنده , , S?ndor Antus، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2009
Pages
4
From page
6738
To page
6741
Abstract
A series of N-(β-d-glucopyranosyl)amides 5d–i were synthesized by PMe3 mediated Staudinger reaction of O-peracetylated β-d-glucopyranosyl azide (1) followed by acylation with carboxylic acids 3d–i and subsequent Zemplén deacetylation. The new compounds were tested for their inhibitory activity against rabbit muscle glycogen phosphorylase and the structure–activity relationships of these compounds are also discussed in this paper.
Keywords
N-(?-d-Glucopyranosyl)amide , Benzodioxane , Inhibitor , Glycogen phosphorylase
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2009
Journal title
Bioorganic and Medicinal Chemistry
Record number
1306367
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