Title of article
Solution-phase parallel synthesis of substituted chalcones and their antiparasitary activity against Giardia lamblia Original Research Article
Author/Authors
Julio Montes-Avila، نويسنده , , Sylvia P. D?az-Camacho، نويسنده , , Josefina Sicairos-Félix، نويسنده , , Francisco Delgado-Vargas، نويسنده , , I.A. Rivero، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2009
Pages
6
From page
6780
To page
6785
Abstract
A library of 25-membered chalcones was prepared by parallel synthesis. Substituted acetophenones and benzaldehydes were condensed using the Claisen–Schmidt base-catalyzed aldol condensation. Several chalcones showed in vitro antiparasitic activity against Giardia lamblia. The highest activity observed for the IC50 values were 12.72, 15.05 and 15.31 μg/mL, respectively; these are potential leads for the development of antigiardial compounds.
Keywords
parallel synthesis , Antiparasitary , Giardia lamblia , Chalcones
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2009
Journal title
Bioorganic and Medicinal Chemistry
Record number
1306373
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