Title of article
Design, synthesis and antibacterial activity of novel andrographolide derivatives Original Research Article
Author/Authors
Zhongli Wang، نويسنده , , Pei Yu، نويسنده , , Gaoxiao Zhang، نويسنده , , Lipeng Xu، نويسنده , , Dingyuan Wang، نويسنده , , Liang Wang، نويسنده , , Xiangping Zeng، نويسنده , , Yuqiang Wang، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2010
Pages
6
From page
4269
To page
4274
Abstract
A series of andrographolide derivatives were synthesized through a facile condensation reaction with different carboxylic acids. The new compounds were characterized and screened for their antibacterial activities. A number of the new compounds significantly reduced bacterial quorum sensing virulence factors production in Pseudomonas aeruginosa, essential for pathogenesis. Compound 11b showed the best activity among all the new compounds.
Keywords
Andrographolide derivatives , Antibacterial , Quorum sensing , Synthesis
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2010
Journal title
Bioorganic and Medicinal Chemistry
Record number
1306534
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