Title of article
Design and synthesis of novel benzimidazole derivatives as inhibitors of hepatitis B virus Original Research Article
Author/Authors
Yu Luo، نويسنده , , Jia-Ping Yao، نويسنده , , Li Yang، نويسنده , , Chun-Lan Feng، نويسنده , , Wei Tang، نويسنده , , Gui-Feng Wang، نويسنده , , Jian-Pin Zuo، نويسنده , , Wei Lu، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2010
Pages
8
From page
5048
To page
5055
Abstract
A series of novel benzimidazole derivatives were synthesized and evaluated for their anti-hepatitis B virus (HBV) activity and cytotoxicity in the HepG2.2.15 cell line. The preliminary SAR was discussed. Compound 12a, with IC50 <0.41 μM and SI >81.2, was the most promising compound and selected as the benchmark compound for further optimization.
Keywords
Anti-HBV activity , Benzimidazoles
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2010
Journal title
Bioorganic and Medicinal Chemistry
Record number
1306703
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