Title of article
Salicylanilides: Selective inhibitors of interleukin-12p40 production Original Research Article
Author/Authors
Michael E. Brown، نويسنده , , Jeffrey N. Fitzner، نويسنده , , Tracey Stevens، نويسنده , , Wilson Chin، نويسنده , , Clifford D. Wright، نويسنده , , Jim P. Boyce، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
5
From page
8760
To page
8764
Abstract
Interleukin (IL)-12p40, a subunit component of both IL-12 and IL-23, is being widely studied for its role in inflammatory disease. As part of an effort to profile cellular signaling pathways across different cell types, we report salicylanilide inhibitors of IL-12p40 production in stimulated dendritic cells. Based on a hypothesis that a desirable therapeutic profile is one that could block IL-12p40 but not IL-6 production, we engaged in directed analoging. This resulted in salicylanilides with similar IL-12p40 related potency but enhanced selectivity relative to IL-6 production.
Keywords
Interleukin-23 (IL-23) , Interleukin-6 (IL-6) , Interleukin-12p40 (IL-12p40) , Salicylanilide , Interleukin-12 (IL-12)
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2008
Journal title
Bioorganic and Medicinal Chemistry
Record number
1306892
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