Title of article
Synthesis and optimization of thiadiazole derivatives as a novel class of substrate competitive c-Jun N-terminal kinase inhibitors Original Research Article
Author/Authors
Surya K. De، نويسنده , , Vida Chen، نويسنده , , John L. Stebbins، نويسنده , , Li-Hsing Chen، نويسنده , , Jason F. Cellitti، نويسنده , , Thomas Machleidt، نويسنده , , Elisa Barile، نويسنده , , Megan Riel-Mehan، نويسنده , , Russell Dahl، نويسنده , , Li Yang، نويسنده , , Aras Emdadi، نويسنده , , Ria Murphy، نويسنده , , Maurizio Pellecchia، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2010
Pages
7
From page
590
To page
596
Abstract
A series of thiadiazole derivatives has been designed as potential allosteric, substrate competitive inhibitors of the protein kinase JNK. We report on the synthesis, characterization and evaluation of a series of compounds that resulted in the identification of potent and selective JNK inhibitors targeting its JIP-1 docking site.
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2010
Journal title
Bioorganic and Medicinal Chemistry
Record number
1307050
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