Title of article
DNA cleavage activities and mechanism of a novel heterodinuclear macrocyclic complex
Author/Authors
Yuan He، نويسنده , , Xiaohui Wang ، نويسنده , , Hong Zhou، نويسنده , , Zhiquan Pan، نويسنده , , Junbo Li، نويسنده , , Qimao Huang، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2010
Pages
5
From page
314
To page
318
Abstract
A new unsymmetrical bis-furan pendant-armed macrocyclic heterodinuclear Cu(II)Zn(II) complex, [CuZnL(OAc)](ClO4)·3MeCN·H2O(1) (H2L was derived from the condensation between 1,6-bis(2-furyl)-2,5-bis(2-hydroxy-3-formyl-5-bromobenzyl)-2, 5-diazahexane and 1,3-diaminopropane), has been synthesized and characterized by EDS (energy dispersive spectroscopy) and X-ray crystallography determination. The interaction between the complex and calf thymus (CT) DNA was investigated by UV–vis absorption, viscosity experiment, fluorescent and CD spectroscopy. The mechanism of the cleavage of supercoiled DNA (pBR 322DNA) process was also studied. It is proposed that DNA cleavage promoted by the complex occurrence via oxidative mechanism.
Keywords
Heterodinuclear complex , Binding-constants , Viscosity , DNA cleavage
Journal title
Inorganic Chemistry Communications
Serial Year
2010
Journal title
Inorganic Chemistry Communications
Record number
1318405
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