Cyclopalladation of 2-tert-butyl-4,4-dimethyl-2-oxazoline in solution and on silica gel

Cyclopalladation of 2-tert-butyl-4,4-dimethyl-2-oxazoline (1) using Pd(OAc)2 was performed in acetic acid and on silica gel. Treatment of the crude product formed in each reaction with LiCl afforded a dimeric cyclopalladated complex (4) in 76 and 93% yield, respectively. The 1H, 13C{1H} NMR and IR spectroscopy data for complex 4 confirmed the formation of the palladacycle with an (sp3)C–Pd bond and suggested the presence of two geometrical isomers in solution.