Title of article
Rhenium(I) and technetium(I) complexes of a novel pyridyltriazole-based ligand containing an arylpiperazine pharmacophore: Synthesis, crystal structures, computational studies and radiochemistry
Author/Authors
Achour Seridi، نويسنده , , Mariusz Wolff، نويسنده , , Alexandre Boulay، نويسنده , , Nathalie Saffon، نويسنده , , Yvon Coulais، نويسنده , , Claude Picard، نويسنده , , Barbara Machura، نويسنده , , Eric Benoist، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2011
Pages
5
From page
238
To page
242
Abstract
The preparation of two M(CO)3 complexes (M = Re and 99mTc) from a novel pyridyltriazole-based ligand 2 bearing the bioactive (2-methoxyphenyl)piperazine pharmacophore are described. Spectral data, X-ray structure and DFT calculations of the rhenium(I) complex as well as the 99mTc-labelling of 2 are reported. Both complexes were neutral and iso-structural. Moreover, the 99mTc-complex presented a suitable lipophilic character for its use as a CNS imaging agent.
Keywords
Rhenium , X-ray structure , Technetium , DFT calculations , Click chemistry , Bidentate ligands
Journal title
Inorganic Chemistry Communications
Serial Year
2011
Journal title
Inorganic Chemistry Communications
Record number
1318792
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