Title of article
Benzylamidine complexes of platinum(II) derived by nucleophilic addition of primary and secondary amines. X-ray crystal structure of trans-[PtCl2{Z-N(H)C(NHMe)CH2Ph}2]
Author/Authors
Silvia Mazzega Sbovata، نويسنده , , Silvia Mazzega and Bettio، نويسنده , , Frazia and Marzano، نويسنده , , Christine and Mozzon، نويسنده , , Mirto and Bertani، نويسنده , , Roberta and Benetollo، نويسنده , , Franco and Michelin، نويسنده , , Rino A.، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
8
From page
3109
To page
3116
Abstract
The reaction of cis- and trans-[PtCl2(NCCH2Ph)2] with a 5-fold excess of MeNH2 and Me2NH in CH2Cl2 at −10 °C affords in high yield the bis-amidine derivatives cis- and trans-[PtCl2{Z-N(H)C(NHMe)CH2Ph}2] (1a, 2a) and cis- and trans-[PtCl2{E-N(H)C(NMe2)CH2Ph}2] (3a, 4a), respectively. The complexes were characterized by means of elemental analysis, multinuclear NMR and FT-IR techniques. The X-ray diffraction analysis was carried out for trans-[PtCl2{Z-N(H)C(NHMe)CH2Ph}2] (2a).
er, the in vitro cytotoxicity for the new derivatives was evaluated in a wide panel of human tumor cell lines.
Keywords
crystal structure , Amidine complexes , cytotoxic activity , Platinum(II)
Journal title
INORGANICA CHIMICA ACTA
Serial Year
2008
Journal title
INORGANICA CHIMICA ACTA
Record number
1326258
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