Title of article
Synthesis, crystal structure and NMR investigation of novel Ca(II) complexes with heterocyclic alcohol, aldehyde and carboxylate ligands. Evaluation of Ca(II) and Cd(II) analogues for anticancer activity
Author/Authors
Barszcz، نويسنده , , Barbara and Masternak، نويسنده , , Joanna and Hodorowicz، نويسنده , , Maciej and Matczak-Jon، نويسنده , , Ewa and Jab?o?ska-Wawrzycka، نويسنده , , Agnieszka and Stadnicka، نويسنده , , Katarzyna and Zienkiewicz، نويسنده , , Ma?gorzata and Kr?lewska، نويسنده , , Karolina and Ka?mierczak-Bara?ska، نويسنده , , Julia، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2013
Pages
10
From page
85
To page
94
Abstract
Three new calcium(II) complexes with heterocyclic alcohol (2-hydroxymethylpyridine), aldehyde (4-methyl-5-carbaldehydeimidazole) and carboxylate (picolinate, obtained in situ) moieties were synthesised and characterised using elemental analysis, X-ray, IR (Raman), 1H, and 13C NMR methods. In addition, we compared the X-ray results obtained for calcium(II) complexes with the structures of previously described cadmium compounds, which from the chemical point of view (HSAB and Lewis acids and bases theories) can give some information for the ability of Cd2+ to mimic Ca2+ ions in biological systems too. The studied ligands, calcium compounds (1–3) and cadmium analogues were tested for their cytotoxicity against HeLa (cervical carcinoma), K562 (leukaemia) and normal cells (HUVEC) using a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay.
Keywords
cytotoxicity , X-Ray , Chelating ligands , 1H and 13C NMR , Calcium(II) and cadmium(II) complexes
Journal title
INORGANICA CHIMICA ACTA
Serial Year
2013
Journal title
INORGANICA CHIMICA ACTA
Record number
1331834
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