Title of article
Stereospecific ligands and their complexes. Part XV. Synthesis, characterization and cytotoxicity of novel platinum(IV) complexes with some esters of ethylenediamine-N,,N’N′-di-S,,S-(2,2′’-dibenzyl)acetic acid. Crystal structure of O,,O′’-dipropyl-ethylen
Author/Authors
Dimitrijevi?، نويسنده , , Dejana P. and Glo?ovi?، نويسنده , , Verica V. and Radi?، نويسنده , , Gordana P. and Garc?a-Granda، نويسنده , , Santiago and Menéndez-Taboada، نويسنده , , Laura and Milovanovi?، نويسنده , , Marija and Volarevi?، نويسنده , , Vladislav and Arsenijevi?، نويسنده , , Neboj?a and Bogdanovi?، نويسنده , , Goran A. and Trifunovi?، نويسنده , , Sre?ko R.، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2013
Pages
7
From page
83
To page
89
Abstract
The synthesis of ethylenediamine-N,,N′’-di-S,,S-(2,2′’-dibenzyl)acetic acid (H2-S,,S-eddba) and its ethyl-, propyl-, butyl- esters (R2-S,,S-eddba) are reported here. The esters were used for synthesis of the corresponding platinum(IV) complexes, [PtCl4(R2-S,,S-eddba)]. The compounds were characterized by elemental analysis, infrared, 1H and 13C NMR spectroscopy. The structure of propyl ester of H2-S,,S-eddba was confirmed by single-crystal X-ray analysis. All [PtCl4(R2-S,,S-eddba)] complexes displayed significantly higher in vitro cytotoxicity in comparison to cisplatin.
Keywords
Platinium(IV) complexes , Citotoxity , X-ray diffraction , Infrared spectra , NMR spectra
Journal title
INORGANICA CHIMICA ACTA
Serial Year
2013
Journal title
INORGANICA CHIMICA ACTA
Record number
1331918
Link To Document