Title of article
Preferential response of cancer cells to zebularine
Author/Authors
Cheng، نويسنده , , Jonathan C. and Yoo، نويسنده , , Christine B. and Weisenberger، نويسنده , , Daniel J. and Chuang، نويسنده , , Jody and Wozniak، نويسنده , , Chandra and Liang، نويسنده , , Gangning and Marquez، نويسنده , , Victor E. and Greer، نويسنده , , Sheldon and Orntoft، نويسنده , , Torben F. and Thykjaer، نويسنده , , Thomas and Jones، نويسنده , , Peter A.، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
8
From page
151
To page
158
Abstract
The frequent silencing of tumor suppressor genes by altered cytosine methylation and chromatin structural changes makes this process an attractive target for epigenetic therapy. Here we show that zebularine, a stable DNA cytosine methylation inhibitor, is preferentially incorporated into DNA and exhibits greater cell growth inhibition and gene expression in cancer cell lines compared to normal fibroblasts. In addition, zebularine preferentially depleted DNA methyltransferase 1 (DNMT1) and induced expression of cancer-related antigen genes in cancer cells relative to normal fibroblasts. Our results demonstrate that zebularine can be selective toward cancer cells and may hold clinical promise as an anticancer therapy.
Journal title
Cancer Cell
Serial Year
2004
Journal title
Cancer Cell
Record number
1335461
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