Title of article
MicroRNA Signature Predicts Survival and Relapse in Lung Cancer
Author/Authors
Yu، نويسنده , , Sung-Liang and Chen، نويسنده , , Hsuan-Yu and Chang، نويسنده , , Gee-Chen and Chen، نويسنده , , Chih-Yi and Chen، نويسنده , , Huei-Wen and Singh، نويسنده , , Sher and Cheng، نويسنده , , Chiou-Ling and Yu، نويسنده , , Chong-Jen and Lee، نويسنده , , Yung-Chie and Chen، نويسنده , , Han-Shiang and Su، نويسنده , , Te-Jen and Chiang، نويسنده , , Ching-Cheng and Li، نويسنده , , Han-Ni and Hong، نويسنده , , Qi-Sheng and Su، نويسنده , , Hsin-Yuan and Chen، نويسنده , , Chun-Chieh and Chen، نويسنده , , Wan-Jiun and Liu، نويسنده , , Chun-Chi and Chan، نويسنده , , Wing-Kai and Chen، نويسنده , , Wei J. and Li، نويسنده , , Ker-Chau and Chen، نويسنده , , Jeremy J.W. and Yang، نويسنده , , Pan-Chyr، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
10
From page
48
To page
57
Abstract
Summary
estigated whether microRNA expression profiles can predict clinical outcome of NSCLC patients. Using real-time RT-PCR, we obtained microRNA expressions in 112 NSCLC patients, which were divided into the training and testing sets. Using Cox regression and risk-score analysis, we identified a five-microRNA signature for the prediction of treatment outcome of NSCLC in the training set. This microRNA signature was validated by the testing set and an independent cohort. Patients with high-risk scores in their microRNA signatures had poor overall and disease-free survivals compared to the low-risk-score patients. This microRNA signature is an independent predictor of the cancer relapse and survival of NSCLC patients.
Keywords
CELLCYCLE
Journal title
Cancer Cell
Serial Year
2008
Journal title
Cancer Cell
Record number
1336776
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