Title of article
The Role of SPINK1 in ETS Rearrangement-Negative Prostate Cancers
Author/Authors
Tomlins، نويسنده , , Scott A. and Rhodes، نويسنده , , Daniel R. and Yu، نويسنده , , Jianjun and Varambally، نويسنده , , Sooryanarayana and Mehra، نويسنده , , Rohit and Perner، نويسنده , , Sven and Demichelis، نويسنده , , Francesca and Helgeson، نويسنده , , Beth E. and Laxman، نويسنده , , Bharathi and Morris، نويسنده , , David S. and Cao، نويسنده , , Qi-Ling Cao، نويسنده , , Xuhong and Andrén، نويسنده , , Ove and Fall، نويسنده , , Katja and Johnson، نويسنده , , Laura and Wei، نويسنده , , John T. and Shah، نويسنده , , Rajal B. and Al-Ahmadie، نويسنده , , Hikmat and Eastham، نويسنده , , James A. and Eggener، نويسنده , , Scott E. and Fine، نويسنده , , Samson W. and Hotakainen، نويسنده , , Kristina and Stenman، نويسنده , , Ulf-Hهkan and Tsodikov، نويسنده , , Alex and Gerald، نويسنده , , William L. and Lilja، نويسنده , , Hans and Reuter، نويسنده , , Victor E. and Kantoff، نويسنده , , Phillip W. and Scardino، نويسنده , , Peter T. and Rubin، نويسنده , , Mark A. and Bjartell، نويسنده , , Anders S. and Chinnaiyan، نويسنده , , Arul M. Chinnaiyan، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
10
From page
519
To page
528
Abstract
Summary
ne fusions have been characterized in a majority of prostate cancers; however, the key molecular alterations in ETS-negative cancers are unclear. Here we used an outlier meta-analysis (meta-COPA) to identify SPINK1 outlier expression exclusively in a subset of ETS rearrangement-negative cancers (∼10% of total cases). We validated the mutual exclusivity of SPINK1 expression and ETS fusion status, demonstrated that SPINK1 outlier expression can be detected noninvasively in urine, and observed that SPINK1 outlier expression is an independent predictor of biochemical recurrence after resection. We identified the aggressive 22RV1 cell line as a SPINK1 outlier expression model and demonstrate that SPINK1 knockdown in 22RV1 attenuates invasion, suggesting a functional role in ETS rearrangement-negative prostate cancers.
Keywords
CELLBIO , HUMDISEASE
Journal title
Cancer Cell
Serial Year
2008
Journal title
Cancer Cell
Record number
1336832
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