Title of article
A Hierarchy of Self-Renewing Tumor-Initiating Cell Types in Glioblastoma
Author/Authors
Chen، نويسنده , , Ruihuan and Nishimura، نويسنده , , Merry C. and Bumbaca، نويسنده , , Stephanie M. and Kharbanda، نويسنده , , Samir and Forrest، نويسنده , , William F. and Kasman، نويسنده , , Ian M. and Greve، نويسنده , , Joan M. and Soriano، نويسنده , , Robert H. and Gilmour، نويسنده , , Laurie L. and Rivers، نويسنده , , Celina Sanchez and Modrusan، نويسنده , , Zora and Nacu، نويسنده , , Serban and Guerrero، نويسنده , , Steve and Edgar، نويسنده , , Kyle A. and Wallin، نويسنده , , Jeffrey J. and Lamszus، نويسنده , , Katrin and Westphal، نويسنده , , Manfred and Heim، نويسنده , , Susanne and James، نويسنده , , C. David and VandenBerg، نويسنده , , Scott R. and Costello، نويسنده , , Joseph F. and Moorefield، نويسنده , , Scott and Cowdrey، نويسنده , , Cynthia J. and Prados، نويسنده , , Michael and Phillips، نويسنده , , Heidi S.، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2010
Pages
14
From page
362
To page
375
Abstract
Summary
ural stem cell marker CD133 is reported to identify cells within glioblastoma (GBM) that can initiate neurosphere growth and tumor formation; however, instances of CD133− cells exhibiting similar properties have also been reported. Here, we show that some PTEN-deficient GBM tumors produce a series of CD133+ and CD133− self-renewing tumor-initiating cell types and provide evidence that these cell types constitute a lineage hierarchy. Our results show that the capacities for self-renewal and tumor initiation in GBM need not be restricted to a uniform population of stemlike cells, but can be shared by a lineage of self-renewing cell types expressing a range of markers of forebrain lineage.
Keywords
CELLCYCLE
Journal title
Cancer Cell
Serial Year
2010
Journal title
Cancer Cell
Record number
1337092
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