• Title of article

    Mdm2ʹs Dilemma: To Degrade or To Translate p53?

  • Author/Authors

    Hamard، نويسنده , , Pierre-Jacques and Manfredi، نويسنده , , James J.، نويسنده ,

  • Issue Information
    روزنامه با شماره پیاپی سال 2012
  • Pages
    3
  • From page
    3
  • To page
    5
  • Abstract
    In this issue of Cancer Cell, Gajjar et al. provide insight into how Mdm2 can both inhibit and enhance p53 activity. In the basal setting, Mdm2 binds p53 and promotes p53 degradation. Under stress conditions, ATM-dependent phosphorylation of Mdm2 results in its recruitment to p53 mRNA, thereby stimulating p53 translation.
  • Journal title
    Cancer Cell
  • Serial Year
    2012
  • Journal title
    Cancer Cell
  • Record number

    1337749

    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=1337749