Mean Platelet Volume asa Predictorof One-Year Major Adverse Cardiac Events followingElective Percutaneous Coronary Interventions

Background: Mean platelet volume (MPV) correlates with platelet activity.The relation between MPV and long-term outcome in patients undergoing percutaneous coronary intervention (PCI) has been investigated in several studies.The aim ofthe present study was to investigate the utility of MPV in prognosticatingthe long-term outcome after elective PCI. Methods:The study cohort included2627 patients undergoing electivePCI between September 2008 and June 2010,whose baseline MPV measurements before PCI were available. The patients were divided into three groups of MPV < 9.1 fL, MPV = 9.1 to 10 fL, and MPV > 10 fL, and they were assessed for developing major adverse cardiac events (MACE), comprising death, myocardial infarction (MI), target vessel revascularization (TVR), and target lesion revascularization (TLR) over a one-year follow-up. Results:Of 2539 patients, major adverse cardiac events (MACE) at one year occurred in 77 (3.0%) patients, including mortality in 26 (1.0%). The patients in the highest tertile (MPV > 10fL) had no increasedfrequency of MACE compared to those in the mid (9.1 to 10fL) and lowest( < 9.1 fL) tertiles (3.3%, 2.2%, and 3.8%, respectively; p value =0.14). No significant differences were found for each of the primary endpoints among the MPV tertiles. In multivariate logistic regression, we investigated the association between high MPV and total MACE (OR=1.10, 95%CI: 0.69-1.77;p value = 0.68), death (OR=1.14,95%CI: 0.51-2.54;p value = 0.74), and non-fatal MI (OR=1.85, 95%CI: 0.73-4.67;p value =0.19) at oneyearʹs follow-up but MPV did not remain in the model in any of the cases. In the diabetic patients, the one-way analysis of variance demonstrated that mortality was 1.6% (4 patients) in the highest tertile, 0.8% (2 patients) in the mid tertile, and 0.5% (one patient) in the lowest tertile. Conclusion: There was no direct correlation between pre-proceduralMPV and MACE in elective PCI. MPV can only be considered as an appropriate factor for predicting mortality in diabetic patients undergoing elective PCI.