• Title of article

    Synthetic studies of salinosporamide A through the intramolecular hydroamidation of alkynes

  • Author/Authors

    Haruhi Kamisaki، نويسنده , , Yusuke Kobayashi، نويسنده , , Tetsutaro Kimachi، نويسنده , , Yoshizumi Yasui، نويسنده , , Yoshiji Takemoto، نويسنده ,

  • Issue Information
    دوفصلنامه با شماره پیاپی سال 2011
  • Pages
    4
  • From page
    42
  • To page
    45
  • Abstract
    Rhodium-catalyzed intramolecular hydroamidation of alkynes was carried out to construct the synthetic intermediates of a proteasome inhibitor, salinosporamide A. Several alkynyl formamides were synthesized and subjected to the hydroamidation reaction. Some derivatives with a methoxymethyl (MOM) or 2-methoxy-2-propyl (MOP) group near the reaction site were converted to the corresponding lactams in excellent yields.
  • Keywords
    alkynes , C–H activation , Hydroamidation , Rhodium carbonyl complexes , ?-Lactams
  • Journal title
    Journal of Organometallic Chemistry
  • Serial Year
    2011
  • Journal title
    Journal of Organometallic Chemistry
  • Record number

    1373475

    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=1373475