Title of article
Ru-catalyzed enantioselective preparation of methyl (R)-o-chloromandelate and its application in the synthesis of (S)-Clopidogrel
Author/Authors
Lu Yin، نويسنده , , Wenjun Shan، نويسنده , , Xian Jia، نويسنده , , Xingshu Li، نويسنده , , Albert S.C. Chan، نويسنده ,
Issue Information
دوفصلنامه با شماره پیاپی سال 2009
Pages
4
From page
2092
To page
2095
Abstract
The preparation of methyl (R)-o-chloromandelate via Ru-catalyzed asymmetric hydrogenation and transfer hydrogenation was investigated. With Ru-(R,R)-2,4,6-triisopropyl C6H2SO2-DPEN as the catalyst and HCOOH–Et3N azeotrope as the hydrogen donor, up to 92% ee was obtained in an optional condition. The synthesis of (S)-Clopidogrel was also studied.
Keywords
Ru-catalyzed , Transfer hydrogenation , Enantioselective , Methyl (R)-o-chloromandelate , (S)-Clopidogrel
Journal title
Journal of Organometallic Chemistry
Serial Year
2009
Journal title
Journal of Organometallic Chemistry
Record number
1374416
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