Title of article
An efficient and mild ortho-zincation of aromatics and heterocycles by using TMP2Mg·2LiCl in the presence of ZnCl2
Author/Authors
Zhi-Bing Dong، نويسنده , , Weihua Zhu، نويسنده , , Zhiguang Zhang، نويسنده , , Min-Zhi Li، نويسنده ,
Issue Information
دوفصلنامه با شماره پیاپی سال 2010
Pages
6
From page
775
To page
780
Abstract
A variety range of functionalized aryl and heteroaryl zinc reagents were efficiently generated by using TMP2Mg·2LiCl (TMP = 2,2,6,6-tetramethylpiperamidyl) in the presence of ZnCl2. The subsequently functionalization gave after reaction with electrophiles the expected polyfunctionalized products in good yields. A detailed study concerned on the point how we found the protocol and how we optimized it was depicted.
Keywords
Aromatics , Heterocycles , metalation , Functionalization , Zincation
Journal title
Journal of Organometallic Chemistry
Serial Year
2010
Journal title
Journal of Organometallic Chemistry
Record number
1375209
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