Title of article
Tuning the anticancer activity of maltol-derived ruthenium complexes by derivatization of the 3-hydroxy-4-pyrone moiety
Author/Authors
Wolfgang Kandioller، نويسنده , , Christian G. Hartinger، نويسنده , , Alexey A. Nazarov، نويسنده , , Johanna Kasser، نويسنده , , Roland John، نويسنده , , Michael A. Jakupec، نويسنده , , Vladimir B. Arion، نويسنده , , Paul J. Dyson، نويسنده , , Bernhard K. Keppler، نويسنده ,
Issue Information
دوفصلنامه با شماره پیاپی سال 2009
Pages
8
From page
922
To page
929
Abstract
Organometallic ruthenium(II)-arene complexes coordinated to maltol-derived ligands were prepared and their anticancer activity against human tumor cell lines was studied. In addition, their hydrolysis behavior and reaction with 5′-GMP was tested and compared to the parent compound chlorido[2-methyl-3-(oxo-κO)-pyran-4(1H)-onato-κO4](η6-p-cymene)ruthenium(II) (Ru-maltol). Improved stability and in vitro anticancer activity at maintained GMP binding capability were observed, in comparison to the Ru-maltol complex.
Keywords
Hydrolysis , pyrone , Antitumor agents , Bioorganometallic chemistry , Ruthenium(II)-arene complex , 5?-GMP binding
Journal title
Journal of Organometallic Chemistry
Serial Year
2009
Journal title
Journal of Organometallic Chemistry
Record number
1375757
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