Title of article
Combining Q2MM modeling and kinetic studies for refinement of the osmium-catalyzed asymmetric dihydroxylation (AD) mnemonic
Author/Authors
Peter Fristrup، نويسنده , , Gitte Holm Jensen، نويسنده , , Marie Louise Nygaard Andersen، نويسنده , , DAVID TANNER، نويسنده , , Per-Ola Norrby، نويسنده ,
Issue Information
دوفصلنامه با شماره پیاپی سال 2006
Pages
17
From page
2182
To page
2198
Abstract
The interactions between the substrate and the ligand in the Sharpless AD reaction have been examined in detail, using a combination of substrate competition experiments and molecular modeling of transition states. There is a good agreement between computational and experimental results, in particular for the stereoselectivity of the reaction. The influence of each moiety in the second-generation ligand (DHQD)2PHAL on the rate and selectivity of the reaction has been elucidated in detail.
Keywords
Dihydroxylation , kinetics , Osmium , Molecular modeling , Asymmetric synthesis
Journal title
Journal of Organometallic Chemistry
Serial Year
2006
Journal title
Journal of Organometallic Chemistry
Record number
1379320
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