In vitro reactivity of Sr-containing bioactive glass (type 1393) nanoparticles

Nanosized bioactive glass (nBG) particles show high in vitro reactivity as a result of their high specific surface making them promising materials for bone tissue engineering. In this study, we investigate the in vitro reactivity of Sr-containing nanosized bioactive glass particles (type 1393) in simulated body fluid (SBF). Hydroxyapatite (HAp) formation was monitored by Fourier Transform Infrared (FT-IR) spectroscopy and X-ray diffraction (XRD) showing that HAp crystallization was delayed with increasing Sr-content due to the inhibitory effect of Sr on HAp mineralization. The HAp forming ability of bioactive glasses gives insight into their surface reactivity which is relevant for application of nanoscaled bioactive glass particles in bone regeneration.