• Title of article

    Glutamyl Adenylate Analogues Are Inhibitors of Glutamyl-tRNA Synthetase

  • Author/Authors

    Desjardins، نويسنده , , Michel and Garneau، نويسنده , , Sylvie and Desgagnés، نويسنده , , Julie and Lacoste، نويسنده , , Lucille and Yang، نويسنده , , Fu and Lapointe، نويسنده , , Jacques and Chênevert، نويسنده , , Robert، نويسنده ,

  • Issue Information
    روزنامه با شماره پیاپی سال 1998
  • Pages
    13
  • From page
    1
  • To page
    13
  • Abstract
    Glutamol adenylate10was a competitive inhibitor (Ki= 3 μM) of glutamyl-tRNA synthetase fromEscherichia coli. TheN6-benzoyl adenine derivative9was also an inhibitor (Ki∼ 60 μM). Replacement of adenine by other bases (purine, cytosine, dihydrocytosine, uridine) resulted in a more than 1000-fold loss in activity, indicating the important contribution of the adenine ring to the enzyme binding.
  • Journal title
    Bioorganic Chemistry: an International Journal
  • Serial Year
    1998
  • Journal title
    Bioorganic Chemistry: an International Journal
  • Record number

    1385241

    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=1385241