Title of article
Synthesis, antitumor activity and QSAR studies of some 4-aminomethylidene derivatives of edaravone
Author/Authors
Markovi?، نويسنده , , Violeta and Eri?، نويسنده , , Slavica and Jurani?، نويسنده , , Zorica D. and Stanojkovi?، نويسنده , , Tatjana and Joksovi?، نويسنده , , Ljubinka and Rankovi?، نويسنده , , Branislav and Kosani?، نويسنده , , Marijana and Joksovi?، نويسنده , , Milan D.، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2011
Pages
10
From page
18
To page
27
Abstract
A series of aminomethylidene derivatives obtained from 4-formyledaravone were synthesized and characterized by IR, NMR and elemental analysis. All the compounds were screened for their antitumor activity. The compound containing 5-phenylpyrazole moiety (3q) exhibited remarkable antitumor activity in in vitro assays, especially against human breast cancer MDA-MB-361 and MDA-MB-453 cell lines. The most important whole-molecule descriptors for antitumor activity on MDA-MB-453 cells belong to the group of quantum-chemical descriptors.
Keywords
Antitumor activity , Edaravone derivatives , QSAR studies
Journal title
Bioorganic Chemistry: an International Journal
Serial Year
2011
Journal title
Bioorganic Chemistry: an International Journal
Record number
1386108
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