A highly repeatable technique for introducing solids and liquids into a supercritical fluid solvent

Recent interest in studying molecular interactions in supercritical fluid environments has raised several important experimental questions. Chief among those is how to prepare a supercritical fluid environment when beginning with a sample of mixed phases at standard ambient temperature and pressure. We present a reliable technique for mixing a gas phase solvent with a liquid co-solvent and a solid phase molecule of interest. Furthermore, this technique is generally applicable to many experimental investigations involving supercritical fluids.