Tandem Staudinger-Aza-Wittig reaction in supercritical CO2: Synthesis of a pharmaceutical interest compound

The aim of this research was to investigate the capability of using supercritical CO2 (scCO2) as reagent and solvent in the synthesis of pharmaceutical cyclodextrinyl derivatives in smooth reaction conditions. In this way we have followed the kinetics of a synthesis which was previously realized in DMF, by using tandem Staudinger-Aza-Wittig (S.A.W.) reaction in scCO2 at 200 bars pressure in a 100 mL reactor. The results show that the reaction in scCO2 showed a second order kinetics with the yield of 92%.