Title of article
Synthesis and the combination effects of dihydropyridine analogs with selected antibiotics against resistant Staphylococcus aureus
Author/Authors
Akbarzadeh، T. نويسنده , , Motagian، S. نويسنده Department of Pharmaceutical Biotechnology and Biotechnology Research Center, Faculty of Pharmacy, Tehran University of Medical sciences, Tehran, I.R.Iran. , , Fallah Tafti، A. نويسنده Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical sciences, Tehran, I.R.Iran. , , Shafiee، A. نويسنده , , Shahverdi، A.R. نويسنده Department of Pharmaceutical Biotechnology and Biotechnology Research Center, Faculty of Pharmacy, Tehran University of Medical sciences, Tehran, I.R.Iran. ,
Issue Information
دوفصلنامه با شماره پیاپی 0 سال 2008
Pages
7
From page
87
To page
93
Abstract
Bacterial resistance is a major drawback in chemotherapy of infectious diseases. In this investigation a new series of 3,5-diarylamide dihydropyridines containing 2-benzylsulfonylimidazol at 4 position have been synthesized and studied for their enhancing effect on the antibacterial activities of different penicillins against a resistant clinical isolate of Staphylococcus aureus using disc diffusion method. During preliminary screening, compound 6d showed the most enhancing effect on the antibacterial activity of amoxicillin against the test strain and the combination effect of this compound has been further studied with penicillin G and piperacillin against S. aureus. The result of this evaluation showed that the antibacterial activities of penicillin G and piperacillin can be also enhanced by compound 6d suggesting a possible utilization of this compound in combination therapy against penicillin resistant S. aureus.
Journal title
Research in Pharmaceutical Sciences
Serial Year
2008
Journal title
Research in Pharmaceutical Sciences
Record number
1435183
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