Electrochemical sensing of the genotoxicity of the micron LiFePO4 rice granule using a guanine biosensor based on LiFePO4/HCl/K2S2O8 System

In order to investigate the genotoxicity of the micron LiFePO4 rice granule, an electrochemical biosensor based on determination of guanine (G) oxidative damage induced by the LiFePO4/HCl/K2S2O8 system was developed. In the LiFePO4/HCl/K2S2O8 system, the reaction of the micron LiFePO4 rice granule with HCl produced Fe2+, and the produced Fe2+ would further react with S2O82−, generating sulfate radical (SO4−) which could severely damage the guanine bases that was immobilized on a glassy carbon electrode (GCE) surface by electro-deposition. The square wave voltammetry (SWV) signal change of the guanine bases was used to monitor the guanine damage. The present work provided a simple electrochemical approach for screening the potential genotoxicity of particulate matters and chemicals in vitro, and it also had potential application in investigating some chemicals anti-oxidation property.