Title of article
Normal-phase and stability-indicating reversed-phase high-performance liquid chromatographic methods for the determination of the novel antitumor agent: 1-methylpropyl-2-imidazolyldisulfide
Author/Authors
Hashash، نويسنده , , Ahmad and Lynn Kirkpatrick، نويسنده , , D and Egorin، نويسنده , , Merrill J and Block، نويسنده , , Lawrence H and Lazo، نويسنده , , John S، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2002
Pages
8
From page
239
To page
246
Abstract
1-Methylpropyl-2-imidazolyl disulfide (MID) is a novel antitumor agent currently in Phase I clinical trials. The chromatographic behavior of MID and its potential impurity, degradation product, and metabolite 2-mercaptoimidazole (2MI) was studied under reversed-phase (RP) and normal-phase (NP) conditions. Both RP- and NP-HPLC separation methods were developed. RP-HPLC was validated as a stability-indicating assay for MID. NP-HPLC retained both MID and 2MI and pending further validation, could prove useful in the study of MID pharmacokinetics.
Keywords
1-Methylpropyl-2-imidazolyldisulphide
Journal title
Journal of Chromatography B
Serial Year
2002
Journal title
Journal of Chromatography B
Record number
1453248
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