Proteomic analysis of dental tissues

Teeth are highly refined structures formed by several types of specialised cell. Tooth formation embraces many areas of biomedical interest, including cellular mechanisms for calcium handling, protein secretion and mineralised tissue production. Proteomics offers great potential to elucidate these cellular roles, and to establish their relevance to general cell types. Here we review our proteomic investigations of dental enamel formation, covering both the approaches taken and some findings of general biomedical relevance.