Title of article
New iron(II) cyclopentadienyl derivative complexes: Synthesis and antitumor activity against human leukemia cancer cells
Author/Authors
Valente، نويسنده , , Andréia C. Santos، نويسنده , , Ana Margarida and Côrte-Real، نويسنده , , Leonor and Robalo، نويسنده , , M. Paula and Moreno، نويسنده , , Virtudes and Font-Bardia، نويسنده , , Mercè and Calvet، نويسنده , , Teresa and Lorenzo، نويسنده , , Julia B. Garcia، نويسنده , , M. Helena، نويسنده ,
Issue Information
دوفصلنامه با شماره پیاپی سال 2014
Pages
9
From page
52
To page
60
Abstract
A new family of “FeII(η5-C5H5)” half sandwich compounds bearing a N-heteroaromatic ligand coordinated to the iron center by a nitrile functional group has been synthesized and fully characterized by NMR and UV–Vis spectroscopy. X-ray analysis of single crystal was achieved for complexes 1 and 3, which crystallized in the monoclinic P21/c and monoclinic P21/n space groups, respectively. Studies of interaction of these five new complexes with plasmid pBR322 DNA by atomic force microscopy showed very strong and different types of interaction. Antiproliferative tests were examined on human leukemia cancer cells (HL-60) using the MTT assay, and the IC50 values revealed excellent antiproliferative activity compared to cisplatin.
Keywords
Iron(II) , Leukemia cancer cells , Atomic force microscopy (AFM) , apoptosis , cyclopentadienyl
Journal title
Journal of Organometallic Chemistry
Serial Year
2014
Journal title
Journal of Organometallic Chemistry
Record number
1458572
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