Title of article
A simple high performance liquid chromatography assay for monitoring plasma concentrations of tipranavir in HIV infected patients
Author/Authors
Dailly، نويسنده , , E. and Reliquet، نويسنده , , V. and Victorri-Vigneau، نويسنده , , C. and Raffi، نويسنده , , F. and Jolliet، نويسنده , , P.، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
4
From page
317
To page
320
Abstract
A simple HPLC assay to determine plasma concentration of tipranavir is presented. A liquid/liquid extraction of the drugs in ethyl acetate/hexane from 250 μL of plasma is followed by a reversed phase isocratic HPLC assay with UV detection at 205 nm. The imprecision and inaccuracy are lower than 10%, the low limit of quantitation is 0.4 mg/L. Thus, this method can be used for therapeutic drug monitoring of tipranavir in HIV infected patients
Keywords
Tipranavir
Journal title
Journal of Chromatography B
Serial Year
2006
Journal title
Journal of Chromatography B
Record number
1462887
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