Electrochromatography

Although Mould and Synge were credited with the first demonstration of the use of electroosmotic flow to drive a liquid in a thin-layer chromatography system, it was the work of Knox and Grant that extensively detailed much of both the theoretical and practical implications of capillary electrochromatography. This review is aimed at giving a very broad outline of the progression of this technique since the late 1980s up to the present time, including some of the current limitations. Examples will be given of the analysis of a wide variety of materials including neutral, acidic, basic and chiral pharmaceutical compounds, along with some of the instrumentation used for this technique.