Simultaneous optimization of the analysis time and the concentration detectability in open-tubular liquid chromatography

Scott’s OT-LC minimal analysis time problem has been solved analytically and has been extended to thick-film and/or large diameter columns. The optimisation analysis has also been applied to a number of relative performance indexes (Cmax/tanal, Cmax.d/tanal and Cmax.u.d2/tanal) which provide a quantitative insight on the extent to which OT-LC allows to combine short analysis times with a large concentration detectability.