Models of active transport of neurotransmitters in synaptic vesicles

Models of the active transport of neurotransmitters in synaptic vesicles were constructed. The models were used to determine the resting potential at membranes of synaptic vesicles: 40 mV (monoamines and acetylcholine) and −40 mV (glutamate). The potential at the membrane of a synaptic vesicle was almost absent for the transport of GABA and glycine. The neurotransmitter concentration of a cell was 0.1–18 mM at the concentration of neurotransmitters in a vesicle equal to 0.5 M. This result is in qualitative agreement with the relevant experimental data.