Title of article
Regio-selective hydroxysubstitution of fluorobenzoic acid derivatives: facile synthesis of fluorosalicylic acid derivatives
Author/Authors
Umezu، نويسنده , , Kazuto and Tabuchi، نويسنده , , Fumiya and Kimura، نويسنده , , Yoshikazu، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
3
From page
97
To page
99
Abstract
Ortho-substituted fluorine in 2,4-difluorobenzoic acid was found to be regio-selectively replaced to hydroxide by solid sodium hydroxide in 1,3-dimethyl-2-imidazolidinone, to afford 4-fluoro-2-hydroxybenzoic acid in high yield. Several multi-fluoro-substituted benzoic acid derivatives were effectively transformed to the corresponding salicylic acid derivatives under the similar conditions.
Keywords
2 , 4-Difluorobenzoic acid , 4-Fluoro-2-hydroxybenzoic acid , Solid sodium hydroxide , Ortho-substitution
Journal title
Journal of Fluorine Chemistry
Serial Year
2003
Journal title
Journal of Fluorine Chemistry
Record number
1607495
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