Title of article
Synthesis of new β-trifluoromethyl containing GABA and β-fluoromethyl containing N-benzylpyrrolidinones
Author/Authors
Gerus، نويسنده , , Igor I. and Mironets، نويسنده , , Roman V. and Shaitanova، نويسنده , , Elena N. and Kukhar، نويسنده , , Valery P.، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2010
Pages
5
From page
224
To page
228
Abstract
A whole series of 3-(mono-, di-, trifluoro)methyl-substituted N-benzylpyrrolidinones 5a–c was synthesized by deoxyfluorination of corresponding 3-functionalized N-benzylpyrrolidinones. New β-trifluoromethyl containing GABA 4a was obtained in two alternative ways: by successive hydrolysis and hydrogenolysis of 3-trifluoromethyl N-benzylpyrrolidinone 5a and from trifluoroacetone as starting compound.
Keywords
Deoxyfluorination reactions , Trifluoromethyl ketones , Fluoro-containing GABA , DAST , Fluoro-containing pyrrolidinones , Ishikawa reagent , Sulfur tetrafluoride
Journal title
Journal of Fluorine Chemistry
Serial Year
2010
Journal title
Journal of Fluorine Chemistry
Record number
1610800
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