Title of article
A new general approach to 4-substituted-3-halo-2-quinolones
Author/Authors
Zhao، نويسنده , , Shuai and He، نويسنده , , Yan-hong and Wu، نويسنده , , Di and Guan، نويسنده , , Zhi، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2010
Pages
9
From page
597
To page
605
Abstract
A general procedure for the preparation of 4-substituted-3-halo-2-quinolones (halo = F, Cl, Br) utilizing 2-halo diethylphosphonoacetic acids (halo = F, Cl, Br) and o-aminophenylketones as the starting materials is described. The title compounds are obtained by an intramolecular Horner–Wadsworth–Emmons olefination of halogen-containing N-acyl-o-aminophenylketones. The transformation process is generally applicable under mild conditions.
Keywords
2-Quinolones , 4-Substituted-3-fluoro-2-quinolones , 4-Substituted-3-chloro-2-quinolones , 4-Substituted-3-bromo-2-quinolones , Horner–Wadsworth–Emmons olefination
Journal title
Journal of Fluorine Chemistry
Serial Year
2010
Journal title
Journal of Fluorine Chemistry
Record number
1610908
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