Synthesis of polyfluoroalkyl containing thiopyran derivatives and their applications in fluoroorganic chemistry

An overview of syntheses and chemical properties of polyfluoroalkyl 2H- and 4H-thiopyrans, their hydrogenated (3,4- and 3,6-dihydrothiopyrans, and tetrahydrothiopyrans) and S-oxidized derivatives is presented. The first part is devoted to the synthetic methods starting from acyclic or cyclic precursors, and on multicomponent reactions. The second one deals with the chemical properties of thiopyran derivatives such as elimination reactions, [4+2] cycloadditions, sulfur or CC double bond oxidations, and reactions with nucleophiles. The last part is focused on the biological evaluation of polyfluoroalkyl 2H-thiopyrans, especially as potential cardiotonic agents.