Electrochemical synthesis of methyl-3,5,7-trifluoroadamantane-1-carboxylate under recycling use of ionic liquid media

Methyl-3,5,7-trifluoroadamantane-1-carboxylate, a key intermediate for the synthesis of 1-amino-3,5,7-trifluoroadamantane (trifluoroamantadine), was synthesized by the electrochemical fluorination of methyl adamantane-1-caroxylate in pyridine–5HF under constant current conditions. After the reaction, the product was extracted from pyridine–5HF by hexane–CH2Cl2, and recovered pyridine–5HF was used repeatedly.