Title of article
Nucleophilic difluoromethylation of N,N-acetals with TMSCF2SO2Ph reagent promoted by trifluoroacetic acid: A facile access to α-difluoromethylated tertiary amines
Author/Authors
Huang، نويسنده , , Weizhou and Ni، نويسنده , , Chuanfa and Zhao، نويسنده , , Yanchuan and Gao، نويسنده , , Bing and Hu، نويسنده , , Jinbo، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2012
Pages
6
From page
161
To page
166
Abstract
A protocol for the synthesis of difluoromethylated tertiary amines by nucleophilic difluoromethylation of N,N-acetals using TMSCF2SO2Ph reagent is developed. The reaction proceeds smoothly in 1,4-dioxane using K2CO3 as the initiator. A key feature of the reaction is that the in situ generated iminiums (from N,N-acetals and CF3COOH) could be fluoroalkylated in an efficient way.
Keywords
(Phenylsulfonyl)difluoromethylation , Difluoromethylation , Nucleophilic fluoroalkylation , N , N-acetals , Amines
Journal title
Journal of Fluorine Chemistry
Serial Year
2012
Journal title
Journal of Fluorine Chemistry
Record number
1611883
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