Title of article
New approach to 3,3-difluoroallyl alcohol
Author/Authors
Omote، نويسنده , , Masaaki and Miake، نويسنده , , Tatsuya and Tarui، نويسنده , , Atsushi and Sato، نويسنده , , Kazuyuki and Welch، نويسنده , , John T. and Kumadaki، نويسنده , , Itsumaro and Ando، نويسنده , , Akira، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2012
Pages
4
From page
114
To page
117
Abstract
A new difluoroalkene with a triethylsilyl group, 4,4-difluoro-3-(triethylsilyl)- but-3-en-1-ol (1), was synthesized as a new building block for 1,1-difluoro-1-alkenes. Treatment of 1 with sodium hydride in the presence of a catalytic amount of p-methoxyphenol induced SiCsp2 bond dissociation. Subsequent addition of an aldehyde to the reactive intermediate afforded 3,3-difluoroallyl alcohol (9). The reaction was accelerated by added p-methoxyphenol.
Keywords
3-Difluoroallyl alcohol , 1 , 1-Difluoro-1-alkenes , Triethyl(alkenyl)silane , 3
Journal title
Journal of Fluorine Chemistry
Serial Year
2012
Journal title
Journal of Fluorine Chemistry
Record number
1611918
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