Title of article
New approach to synthesize β,β-difluorohomoallylic alcohols
Author/Authors
Omote، نويسنده , , Masaaki and Miake، نويسنده , , Tatsuya and Tarui، نويسنده , , Atsushi and Sato، نويسنده , , Kazuyuki and Kumadaki، نويسنده , , Itsumaro and Ando، نويسنده , , Akira، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2013
Pages
4
From page
1
To page
4
Abstract
Treatment of ethyl 4,4-difluoro-3-(triethylsilyl)but-3-enoate (3) with TBAF in the presence of MS4إ followed by addition of an aromatic aldehyde afforded ethyl (E)-4,4-difluoro-5-hydroxy-5-arylpent-2-enoate (1) that was a versatile intermediate for constructing a stable isostere of peptide or fluorinated sugar molecules. This strategy offers straightforward approach to synthesize such a versatile intermediate (1).
Keywords
? , ?-Difluorohomoallylic alcohol , Triethylsilyl , TBAF
Journal title
Journal of Fluorine Chemistry
Serial Year
2013
Journal title
Journal of Fluorine Chemistry
Record number
1611966
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