Title of article
Stereocontrolled synthesis of dinucleoside phosphorothioates using a fluorous tag
Author/Authors
Oka، نويسنده , , Natsuhisa and Murakami، نويسنده , , Ryosuke and Kondo، نويسنده , , Tomoaki and Wada، نويسنده , , Takeshi، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2013
Pages
7
From page
85
To page
91
Abstract
Dinucleoside phosphorothioates were synthesized in a stereocontrolled manner (diastereoselectivity > 99:1) by using thymidine derivatives bearing a simple perfluoroalkyl tag (C6F13 or C8F17) at the 3′-end and diastereopure nucleoside 3′-O-oxazaphospholidine monomers. Fluorous-tagged intermediates in the synthesis were easily purified by a simple fluorous solid-phase extraction process.
Keywords
Stereocontrolled synthesis , phosphorothioate , fluorous , Oxazaphospholidine
Journal title
Journal of Fluorine Chemistry
Serial Year
2013
Journal title
Journal of Fluorine Chemistry
Record number
1612018
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